Publications
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Wensing L*, Sharma J*, Uthayakumar D, Proteau Y, Chavez A, and Shapiro RS. A CRISPR interference system for efficient genetic repression in Candida albicans. mSphere (2019). 4:e00002-19
Halder V, Porter CBM, Chavez A, and Shapiro RS. Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans. Nature Protocols (2019). 14:955–975
Sharma J, Rosiana S, Razzaq I, and Shapiro RS. Linking cellular morphogenesis with antifungal treatment and susceptibility in Candida pathogens. Journal of Fungi (2019) 5:17.
Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, Gingras A-C, Selmecki A, and Cowen LE.
Functional divergence of a global regulatory complex governing fungal filamentation
PLOS Genetics (2019). doi.org/10.1371/journal.pgen.1007901
Geddes-McAlister J and Shapiro RS
New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics
Annals of the New York Academy of Sciences (2018) doi:0.1111/nyas.13739
Shapiro RS, Chavez A, and Collins JJ
CRISPR-based genomic tools for the manipulation of genetically-intractable microorganisms
Nature Reviews Microbiology (2018) 16:333-339
Veri AO, Miao X, Shapiro RS, Tebbji F, O’Meara TR, Kim SH, Colazo J, Tan K, Whiteway M, Robbins N, Wong KH, and Cowen LE
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space
PLOS Genetics (2018) 14(3):e1007270
Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, and Church GM
Precise Cas9 targeting enables genomic mutation prevention
PNAS (2018) doi.org/10.1073
Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu X, Revtovich AV, Kirienko NV, Wang Y, Church GM, and Collins JJ. (2017)
A CRISPR Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
Nature Microbiology (2017) 3:73-82
Cohen NR, Ross C, Jain S, Shapiro RS, Gutierrez A, Belenky P, Li H, and Collins JJ
A role for the bacterial GATC methylome in antibiotic stress survival
Nature Genetics (2016) 48(5): 581-586
Shapiro RS
Antimicrobial-induced DNA damage and genomic instability in microbial pathogens
PLOS Pathogens (2015) 11(3):e1004678
Gambaro K, Quinn MCJ, Cáceres-Gorriti, KY, Shapiro RS, Provencher D, Rahimi K, Mes-Masson A-M, and Tonin PN
Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome
BMC Cancer (2015) 15(1):1138
Ryan O*, Shapiro RS*, Kurat C, Mayhew D, Baryshnikova A, Chin B, Costanzo M, Lin Z-Y, Cox M, Vizeacoumar F, Cheung D, Tsui K, Istel F, Tebbji F, Sellam A, Schwarzmuller T, Kuchler K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras A-C, Mitra RD, Johnston M, Andrews B, Fink GR, Cowen LE, and Boone C
Global gene deletion analysis exploring yeast filamentous growth
Science (2012) 337(6100):1353-1356
*These authors contributed equally to this work
Shapiro RS, Ryan O, Boone C, and Cowen LE
Regulatory circuitry governing morphogenesis in Saccharomyces cerevisiae and Candida albicans
Cell Cycle (2012) 11(23): 4294-4295
Shapiro RS and Cowen LE
Thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing
mBio (2012) 3(5):e00238
Shapiro RS, Zaas AK, Betancourt-Quiroz M, Perfect JR, and Cowen LE
The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance
PLOS ONE (2012) 7(9):e44734
Shapiro RS, Sellam A, Tebbji F, Whiteway M, Nantel A and Cowen LE
Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise
Current Biology (2012) 22(6):461-470
Shapiro RS and Cowen LE
Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis
Virulence (2012) 3(4):400-404
Senn HE, Shapiro RS and Cowen LE
Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans
Molecular Biology of the Cell (2012) 23(2):268-283
Diezmann S, Michaut M, Shapiro RS, Bader GD, and Cowen LE
Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry
PLOS Genetics (2012) 8(3):e1002562
Shapiro RS*, Robbins N* and Cowen LE
Regulatory circuitry governing fungal development, drug resistance, and disease
Microbiology and Molecular Biology Reviews (2011) 75(2):213-267
Shapiro RS and Cowen LE
Coupling temperature sensing and development: Hsp90 regulates morphogenetic signalling in Candida albicans
Virulence (2010) 1(1):45-48
Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, and Cowen LE
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
Current Biology (2009) 19(8):621-629
Halder V, Porter CBM, Chavez A, and Shapiro RS. Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans. Nature Protocols (2019). 14:955–975
Sharma J, Rosiana S, Razzaq I, and Shapiro RS. Linking cellular morphogenesis with antifungal treatment and susceptibility in Candida pathogens. Journal of Fungi (2019) 5:17.
Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, Gingras A-C, Selmecki A, and Cowen LE.
Functional divergence of a global regulatory complex governing fungal filamentation
PLOS Genetics (2019). doi.org/10.1371/journal.pgen.1007901
Geddes-McAlister J and Shapiro RS
New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics
Annals of the New York Academy of Sciences (2018) doi:0.1111/nyas.13739
Shapiro RS, Chavez A, and Collins JJ
CRISPR-based genomic tools for the manipulation of genetically-intractable microorganisms
Nature Reviews Microbiology (2018) 16:333-339
Veri AO, Miao X, Shapiro RS, Tebbji F, O’Meara TR, Kim SH, Colazo J, Tan K, Whiteway M, Robbins N, Wong KH, and Cowen LE
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space
PLOS Genetics (2018) 14(3):e1007270
Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, and Church GM
Precise Cas9 targeting enables genomic mutation prevention
PNAS (2018) doi.org/10.1073
Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu X, Revtovich AV, Kirienko NV, Wang Y, Church GM, and Collins JJ. (2017)
A CRISPR Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
Nature Microbiology (2017) 3:73-82
Cohen NR, Ross C, Jain S, Shapiro RS, Gutierrez A, Belenky P, Li H, and Collins JJ
A role for the bacterial GATC methylome in antibiotic stress survival
Nature Genetics (2016) 48(5): 581-586
Shapiro RS
Antimicrobial-induced DNA damage and genomic instability in microbial pathogens
PLOS Pathogens (2015) 11(3):e1004678
Gambaro K, Quinn MCJ, Cáceres-Gorriti, KY, Shapiro RS, Provencher D, Rahimi K, Mes-Masson A-M, and Tonin PN
Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome
BMC Cancer (2015) 15(1):1138
Ryan O*, Shapiro RS*, Kurat C, Mayhew D, Baryshnikova A, Chin B, Costanzo M, Lin Z-Y, Cox M, Vizeacoumar F, Cheung D, Tsui K, Istel F, Tebbji F, Sellam A, Schwarzmuller T, Kuchler K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras A-C, Mitra RD, Johnston M, Andrews B, Fink GR, Cowen LE, and Boone C
Global gene deletion analysis exploring yeast filamentous growth
Science (2012) 337(6100):1353-1356
*These authors contributed equally to this work
Shapiro RS, Ryan O, Boone C, and Cowen LE
Regulatory circuitry governing morphogenesis in Saccharomyces cerevisiae and Candida albicans
Cell Cycle (2012) 11(23): 4294-4295
Shapiro RS and Cowen LE
Thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing
mBio (2012) 3(5):e00238
Shapiro RS, Zaas AK, Betancourt-Quiroz M, Perfect JR, and Cowen LE
The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance
PLOS ONE (2012) 7(9):e44734
Shapiro RS, Sellam A, Tebbji F, Whiteway M, Nantel A and Cowen LE
Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise
Current Biology (2012) 22(6):461-470
Shapiro RS and Cowen LE
Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis
Virulence (2012) 3(4):400-404
Senn HE, Shapiro RS and Cowen LE
Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans
Molecular Biology of the Cell (2012) 23(2):268-283
Diezmann S, Michaut M, Shapiro RS, Bader GD, and Cowen LE
Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry
PLOS Genetics (2012) 8(3):e1002562
Shapiro RS*, Robbins N* and Cowen LE
Regulatory circuitry governing fungal development, drug resistance, and disease
Microbiology and Molecular Biology Reviews (2011) 75(2):213-267
Shapiro RS and Cowen LE
Coupling temperature sensing and development: Hsp90 regulates morphogenetic signalling in Candida albicans
Virulence (2010) 1(1):45-48
Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, and Cowen LE
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling
Current Biology (2009) 19(8):621-629